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2017 ; 4
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): ä Nephropedia Template TP
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English Wikipedia
3D Printing of Organs-On-Chips
#MMPMID28952489
Yi HG
; Lee H
; Cho DW
Bioengineering (Basel)
2017[Jan]; 4
(1
): ä PMID28952489
show ga
Organ-on-a-chip engineering aims to create artificial living organs that mimic
the complex and physiological responses of real organs, in order to test drugs by
precisely manipulating the cells and their microenvironments. To achieve this,
the artificial organs should to be microfabricated with an extracellular matrix
(ECM) and various types of cells, and should recapitulate morphogenesis, cell
differentiation, and functions according to the native organ. A promising
strategy is 3D printing, which precisely controls the spatial distribution and
layer-by-layer assembly of cells, ECMs, and other biomaterials. Owing to this
unique advantage, integration of 3D printing into organ-on-a-chip engineering can
facilitate the creation of micro-organs with heterogeneity, a desired 3D cellular
arrangement, tissue-specific functions, or even cyclic movement within a
microfluidic device. Moreover, fully 3D-printed organs-on-chips more easily
incorporate other mechanical and electrical components with the chips, and can be
commercialized via automated massive production. Herein, we discuss the recent
advances and the potential of 3D cell-printing technology in engineering
organs-on-chips, and provides the future perspectives of this technology to
establish the highly reliable and useful drug-screening platforms.
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