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2017 ; 4
(3
): ä Nephropedia Template TP
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3D Bioprinting and In Vitro Cardiovascular Tissue Modeling
#MMPMID28952550
Jang J
Bioengineering (Basel)
2017[Aug]; 4
(3
): ä PMID28952550
show ga
Numerous microfabrication approaches have been developed to recapitulate
morphologically and functionally organized tissue microarchitectures in vitro;
however, the technical and operational limitations remain to be overcome. 3D
printing technology facilitates the building of a construct containing
biomaterials and cells in desired organizations and shapes that have
physiologically relevant geometry, complexity, and micro-environmental cues. The
selection of biomaterials for 3D printing is considered one of the most critical
factors to achieve tissue function. It has been reported that some printable
biomaterials, having extracellular matrix-like intrinsic microenvironment
factors, were capable of regulating stem cell fate and phenotype. In particular,
this technology can control the spatial positions of cells, and provide
topological, chemical, and complex cues, allowing neovascularization and
maturation in the engineered cardiovascular tissues. This review will delineate
the state-of-the-art 3D bioprinting techniques in the field of cardiovascular
tissue engineering and their applications in translational medicine. In addition,
this review will describe 3D printing-based pre-vascularization technologies
correlated with implementing blood perfusion throughout the engineered tissue
equivalent. The described engineering method may offer a unique approach that
results in the physiological mimicry of human cardiovascular tissues to aid in
drug development and therapeutic approaches.
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