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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Am+Soc+Nephrol
2017 ; 28
(5
): 1370-1378
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(Re)Building a Kidney
#MMPMID28096308
Oxburgh L
; Carroll TJ
; Cleaver O
; Gossett DR
; Hoshizaki DK
; Hubbell JA
; Humphreys BD
; Jain S
; Jensen J
; Kaplan DL
; Kesselman C
; Ketchum CJ
; Little MH
; McMahon AP
; Shankland SJ
; Spence JR
; Valerius MT
; Wertheim JA
; Wessely O
; Zheng Y
; Drummond IA
J Am Soc Nephrol
2017[May]; 28
(5
): 1370-1378
PMID28096308
show ga
(Re)Building a Kidney is a National Institute of Diabetes and Digestive and
Kidney Diseases-led consortium to optimize approaches for the isolation,
expansion, and differentiation of appropriate kidney cell types and the
integration of these cells into complex structures that replicate human kidney
function. The ultimate goals of the consortium are two-fold: to develop and
implement strategies for in vitro engineering of replacement kidney tissue, and
to devise strategies to stimulate regeneration of nephrons in situ to restore
failing kidney function. Projects within the consortium will answer fundamental
questions regarding human gene expression in the developing kidney, essential
signaling crosstalk between distinct cell types of the developing kidney, how to
derive the many cell types of the kidney through directed differentiation of
human pluripotent stem cells, which bioengineering or scaffolding strategies have
the most potential for kidney tissue formation, and basic parameters of the
regenerative response to injury. As these projects progress, the consortium will
incorporate systematic investigations in physiologic function of in vitro and in
vivo differentiated kidney tissue, strategies for engraftment in experimental
animals, and development of therapeutic approaches to activate innate reparative
responses.
free
free
free
