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Physiological and pathophysiological regulation of cytochrome P450 Morgan ET; Sewer MB; Iber H; Gonzalez FJ; Lee YH; Tukey RH; Okino S; Vu T; Chen YH; Sidhu JS; Omiecinski CJDrug Metab Dispos 1998[Dec]; 26 (12): 1232-40This article is a report on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 1998 Experimental Biology '98 meeting in San Francisco. The presentations focused on the mechanisms of regulation of cytochrome P450 gene expression by developmental factors and by hormones and cytokines, as well as on the interplay between physiological and chemical regulation. Approaches and systems used to address these questions included conditional gene knockouts in mice, primary hepatocyte cultures, immunofluorescence imaging of cells, and cell lines stably expressing reporter gene constructs.|Animals[MESH]|Cytochrome P-450 Enzyme System/biosynthesis/genetics/*physiology[MESH]|Enzyme Induction/drug effects[MESH]|Gene Expression Regulation, Enzymologic/*physiology[MESH]|Humans[MESH]|Mice[MESH] |
