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Science and pragmatism in the treatment and prevention of neutropenic infection Klastersky JJ Antimicrob Chemother 1998[Jun]; 41 Suppl D (ä): 13-24The following aspects of the management of patients with granulocytopenia and fever are reviewed in this article: adaptation of initial antibiotic regimens to the recent changes in the most common causative pathogens (namely a change from Gram-negative bacteria to Gram-positive bacteria and fungi); subsequent modifications of the empirically administered treatments; improvement of the host's defence by reducing the duration of neutropenia; and indications for out patient therapy of febrile episodes.|*Anti-Bacterial Agents[MESH]|*Antibiotic Prophylaxis[MESH]|Drug Therapy, Combination/*therapeutic use[MESH]|Fever/*immunology[MESH]|Gram-Negative Bacterial Infections/immunology/*prevention & control[MESH]|Humans[MESH]|Mycoses/immunology/*prevention & control[MESH]|Neutropenia/*immunology[MESH]|Opportunistic Infections/immunology/*prevention & control[MESH] |
