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lüll Forty years of beta-lactam research Rolinson GNJ Antimicrob Chemother 1998[Jun]; 41 (6): 589-603For more than 40 years the author has been involved in research in the field of beta-lactam antibiotics. Much of this work was concerned with the development of the semisynthetic penicillins, following the isolation of the penicillin nucleus, 6-aminopenicillanic acid. This work resulted in the introduction of a number of important antibiotics including methicillin, cloxacillin, flucloxacillin, ampicillin, amoxycillin, carbenicillin and ticarcillin. Many of these compounds also provided the incentive or the basis for studies of a more fundamental nature in cell biology and antibacterial chemotherapy. The following is the author's personal account of some of the studies in the beta-lactam field in which he has been involved.|Animals[MESH]|Anti-Bacterial Agents/*history/pharmacology[MESH]|History, 20th Century[MESH]|Humans[MESH]|Methicillin Resistance[MESH]|Penicillins/history[MESH]|Pseudomonas aeruginosa/drug effects[MESH]|Staphylococcus/drug effects/metabolism[MESH]|beta-Lactam Resistance[MESH]|beta-Lactamases/metabolism[MESH]|beta-Lactams[MESH] |