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lüll Borna disease in a dog with lethal meningoencephalitis Weissenbock H; Nowotny N; Caplazi P; Kolodziejek J; Ehrensperger FJ Clin Microbiol 1998[Jul]; 36 (7): 2127-30A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog.|Animals[MESH]|Antigens, Viral/analysis[MESH]|Base Sequence[MESH]|Borna Disease/*virology[MESH]|Borna disease virus/classification/*isolation & purification[MESH]|Brain/ultrastructure/virology[MESH]|Dog Diseases/*virology[MESH]|Dogs[MESH]|Female[MESH]|Immunohistochemistry[MESH]|In Situ Hybridization[MESH]|Meningoencephalitis/*veterinary/virology[MESH]|Molecular Sequence Data[MESH]|Polymerase Chain Reaction/methods[MESH]|RNA, Viral/analysis[MESH] |