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Structural principles in cell-cycle control: beyond the CDKs Endicott JA; Noble MEStructure 1998[May]; 6 (5): 535-41Retinoblastoma protein (Rb) interacts with cyclin-dependent kinases and regulates the transcription of genes necessary for progression through the S phase of the cell cycle. Clues to the atomic mechanisms involved are offered by the structure of the two pocket regions of Rb in complex with a short peptide from a viral oncoprotein. Structures of cyclins, Rb and TFIIB reveal that a common motif occurs in proteins regulating three consecutive events of cell-cycle control.|Amino Acid Sequence[MESH]|Cell Cycle Proteins/*chemistry/metabolism[MESH]|Cell Cycle/*physiology[MESH]|Models, Molecular[MESH]|Molecular Sequence Data[MESH]|Oncogene Proteins, Viral/chemistry/metabolism[MESH]|Papillomaviridae[MESH]|Protein Conformation[MESH]|Retinoblastoma Protein/chemistry/metabolism[MESH]|Sequence Homology, Amino Acid[MESH]|Transcription Factor TFIIB[MESH]|Transcription Factors/chemistry/metabolism[MESH] |
