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lüll "Cognitive dysmetria" as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?Andreasen NC; Paradiso S; O'Leary DSSchizophr Bull 1998[]; 24 (2): 203-18Earlier efforts to localize the symptoms of schizophrenia in a single brain region have been replaced by models that postulate a disruption in parallel distributed or dynamic circuits. Based on empirical data derived from both magnetic resonance and positron emission tomography, we have developed a model that implicates connectivity among nodes located in prefrontal regions, the thalamic nuclei, and the cerebellum. A disruption in this circuitry produces "cognitive dysmetria," difficulty in prioritizing, processing, coordinating, and responding to information. This "poor mental coordination" is a fundamental cognitive deficit in schizophrenia and can account for its broad diversity of symptoms.|*Models, Neurological[MESH]|Brain/diagnostic imaging/pathology/*physiopathology[MESH]|Cerebellum/anatomy & histology/diagnostic imaging/physiopathology[MESH]|Frontal Lobe/diagnostic imaging/pathology/physiopathology[MESH]|Humans[MESH]|Nerve Net/anatomy & histology/physiology[MESH]|Neurobehavioral Manifestations/*physiology[MESH]|Radionuclide Imaging[MESH]|Schizophrenia/complications/diagnostic imaging/pathology/*physiopathology[MESH]|Thalamus/diagnostic imaging/pathology/physiopathology[MESH] |