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The Proteus syndrome: CNS manifestations Dietrich RB; Glidden DE; Roth GM; Martin RA; Demo DSAJNR Am J Neuroradiol 1998[May]; 19 (5): 987-90Proteus syndrome is a complex hamartomatous disorder characterized by multiple, diverse, somatic manifestations. We present a case in which severe, evolving CNS abnormalities were also exhibited. Imaging findings at presentation included hemimegalencephaly, subependymal calcified nodules, and periventricular cysts. Subsequently, dural sinus thrombosis developed. Eight previously reported patients may also have had hemimegalencephaly. When neuroimaging studies show hemimegalencephaly in a child with pigmented skin lesions, Proteus syndrome should be considered in the differential diagnosis.|Brain Diseases/diagnosis/*etiology[MESH]|Cerebral Angiography[MESH]|Child, Preschool[MESH]|Humans[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Proteus Syndrome/*complications[MESH]|Tomography, X-Ray Computed[MESH] |
