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lüll Genetic basis of salt-susceptibility in the Sabra rat model of hypertension Yagil Y; Yagil CKidney Int 1998[Jun]; 53 (6): 1493-500The Sabra salt-sensitive SBH/y and salt-resistant SBN/y rats constitute a unique experimental model of hypertension in which salt-susceptibility is genetically determined and expressed only after salt-loading, without the development of spontaneous hypertension. To determine the genetic basis of salt-susceptibility in the Sabra rats, the candidate gene and total genome screen approaches were adopted. The likely candidate genes in this model incorporate salt-related physiological mechanisms such as the nitric oxide system, the arginine vasopressin axis and the epithelial sodium channel. In the random genome search scheme for culprit genes, SBH/y and SBN/y were cross-bred. A highly unusual and composite mode of transmission of salt-susceptibility was found in this cross, emphasizing the complexity of the genetic basis of salt-susceptibility. Linkage analysis of the entire rat genome with a large number of widely distributed microsatellite markers identified three putative gene loci on chromosomes 1 and 17 that contribute importantly to salt-sensitivity and/or resistance, and uncovered sex specificity in the role that salt-susceptibility genes fulfill in the development of hypertension.|Animals[MESH]|Chromosome Mapping[MESH]|Crosses, Genetic[MESH]|Disease Models, Animal[MESH]|Female[MESH]|Hypertension/*genetics/*physiopathology[MESH]|Immunity, Innate/genetics[MESH]|Male[MESH]|Rats[MESH]|Rats, Inbred Strains/*genetics[MESH]|Sodium Chloride/*pharmacology[MESH] |