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Excimer laser for various degrees of myopia A new model estimating the immediate response, the regression, the final response and the time relationship Edmund CActa Ophthalmol Scand 1998[Apr]; 76 (2): 131-7PURPOSE: To demonstrate a unified model for various degrees of myopia, characterizing the response-time relationship and its influence of topical corticosteroids. METHODS: 84 eyes were treated with excimer laser for myopia (median -7.1 D). 50 eyes received topical NSAID for 4 days (group 1), and 34 eyes (group 2) were further treated postoperatively with bandage lens and topical corticosteroids for three months. The response-time relationship was expressed as P(t)=a+b*exp(k*t), where P(t) is the response expressed as the percent change in dioptric power to the postoperative time t, a is the final percent response, b is the total percent regression and k the time constant. a+b express the percent immediate response and T1/2=0.69/k denote the time within which half of the total regression has occurred. RESULTS: The immediate and final responses were significantly larger in group 2 (128.9% and 70.5%) compared with group 1 (110.5% and 59.8%). T1/2 was significantly longer in group 2 (2.1 month) compared with group 1 (0.8 month) CONCLUSION: Use of bandage lens together with steroids significantly influences the response-time relationship after excimer laser treatment for myopia.|*Laser Therapy[MESH]|Administration, Topical[MESH]|Adrenal Cortex Hormones/therapeutic use[MESH]|Adult[MESH]|Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/therapeutic use[MESH]|Cornea/physiopathology[MESH]|Humans[MESH]|Middle Aged[MESH]|Myopia/drug therapy/physiopathology/*surgery[MESH]|Occlusive Dressings[MESH]|Postoperative Period[MESH]|Refraction, Ocular/physiology[MESH]|Time Factors[MESH]|Treatment Outcome[MESH]|Visual Acuity/physiology[MESH] |
