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Tuberous sclerosis complex and Wolff-Parkinson-White syndrome O'Callaghan FJ; Clarke AC; Joffe H; Keeton B; Martin R; Salmon A; Thomas RD; Osborne JPArch Dis Child 1998[Feb]; 78 (2): 159-62This report highlights the association between tuberous sclerosis and Wolff-Parkinson-White syndrome. Ten patients with concurrent diagnoses of Wolff-Parkinson-White syndrome and tuberous sclerosis were identified. Wolff-Parkinson-White syndrome presented early in life, nine cases being diagnosed in the first year. Eight of the 10 cases were male. In eight cases, the syndrome was associated with supraventricular tachycardias, and in nine with cardiac rhabdomyomata. One child died from cardiac failure secondary to obstruction of the left ventricular outflow tract by a rhabdomyoma. Five of nine survivors showed resolution of Wolff-Parkinson-White syndrome on follow up. The accessory pathway was localised in nine patients from surface electrocardiograms: six children had left sided pathways and three had right sided pathways.|Electrocardiography[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Heart Conduction System/physiopathology[MESH]|Heart Neoplasms/complications/physiopathology[MESH]|Humans[MESH]|Infant[MESH]|Infant, Newborn[MESH]|Male[MESH]|Rhabdomyoma/complications/physiopathology[MESH]|Tuberous Sclerosis/*complications/physiopathology[MESH]|Wolff-Parkinson-White Syndrome/*complications/physiopathology[MESH] |
