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Caspases: key mediators of apoptosis Thornberry NAChem Biol 1998[May]; 5 (5): R97-103Recent studies have established that members of the caspase protease family are essential components of a conserved cell death program. Insights into their biological roles, structure and mechanism are enabling investigators to begin to explore the therapeutic potential of caspase inhibition.|*Apoptosis[MESH]|Animals[MESH]|Catalysis[MESH]|Cysteine Endopeptidases/chemistry/*metabolism[MESH]|Cysteine Proteinase Inhibitors/pharmacology[MESH]|Protein Conformation[MESH]|Substrate Specificity[MESH] |
