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lüll Transcription factors that regulate monocyte/macrophage differentiation Valledor AF; Borras FE; Cullell-Young M; Celada AJ Leukoc Biol 1998[Apr]; 63 (4): 405-17Although all the cells in an organism contain the same genetic information, differences in the cell phenotype arise from the expression of lineage-specific genes. During myelopoiesis, external differentiating signals regulate the expression of a set of transcription factors. The combined action of these transcription factors subsequently determines the expression of myeloid-specific genes and the generation of monocytes and macrophages. In particular, the transcription factor PU.1 has a critical role in this process. We review the contribution of several transcription factors to the control of macrophage development.|*Cell Differentiation[MESH]|*Gene Expression Regulation[MESH]|*Leukopoiesis[MESH]|Animals[MESH]|Humans[MESH]|Macrophages/*physiology[MESH]|Monocytes/*physiology[MESH]|Proto-Oncogene Proteins/physiology[MESH]|Stem Cells/physiology[MESH]|Trans-Activators/physiology[MESH]|Transcription Factors/*physiology[MESH]|Zinc Fingers/physiology[MESH] |