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Transcriptional regulation in the immune system: all roads lead to AP-1 Foletta VC; Segal DH; Cohen DRJ Leukoc Biol 1998[Feb]; 63 (2): 139-52The mechanisms regulating the development and function of the immune system are diverse and complicated. The signaling pathways and target genes that become activated upon cell-surface stimulation are currently being defined, and transcription factor activator protein 1 (AP-1) is proving to be an important regulator of nuclear gene expression in leukocytes. In vitro and in vivo studies have demonstrated that AP-1 expression is induced after a diverse range of stimuli and that AP-1 contributes to the regulation of a large number of genes. In this review we will examine the role of AP-1 during leukocyte activation and differentiation in the immune system.|Animals[MESH]|Antibody Formation[MESH]|Apoptosis[MESH]|B-Lymphocytes/*physiology[MESH]|Cell Differentiation[MESH]|Cytokines/genetics[MESH]|Gene Expression Regulation, Developmental[MESH]|Humans[MESH]|Lymphocyte Activation[MESH]|Protein Binding[MESH]|Receptors, Antigen, B-Cell/*physiology[MESH]|Receptors, Antigen, T-Cell/*physiology[MESH]|Signal Transduction[MESH]|T-Lymphocytes/*physiology[MESH]|Thymus Gland/cytology[MESH]|Transcription Factor AP-1/*physiology[MESH]|Transcription, Genetic[MESH] |
