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lüll Amantadine does not have antiviral activity against Borna disease virus Cubitt B; de la Torre JCArch Virol 1997[]; 142 (10): 2035-42We have investigated the antiviral activity of amantadine (AD) against Borna disease virus (BDV) in several culture cell systems. We present evidence that AD, in the range 5 to 10 microM, does not have antiviral activity against BDV. Treatment of BDV infected cells with AD for six days caused neither a reduction in the number of infected cells, nor a decrease in steady state levels of BDV RNA or proteins. Moreover, treatment of cells with AD prior infection did not affect BDV multiplication, whereas influenza A virus yield was less than 1% with respect to that obtained in untreated control cells.|Amantadine/analogs & derivatives/*pharmacology[MESH]|Animals[MESH]|Antigens, Viral/metabolism[MESH]|Antiviral Agents/*pharmacology[MESH]|Borna disease virus/*drug effects/genetics/metabolism[MESH]|Cell Line[MESH]|Dogs[MESH]|RNA, Viral/metabolism[MESH]|Rabbits[MESH]|Rats[MESH]|Tumor Cells, Cultured[MESH]|Viral Proteins/metabolism[MESH] |