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Moxonidine: a review Morris ST; Reid JLJ Hum Hypertens 1997[Oct]; 11 (10): 629-35Moxonidine is an imidazoline compound which acts on I1 imidazoline 'receptors' in the central nervous system to reduce blood pressure. This novel mechanism of action is claimed to lead to fewer adverse effects than the older centrally-acting agents such as clonidine. In this review we examine the drug's pharmacology, clinical pharmacokinetics, efficacy as an antihypertensive agent including comparative studies with pre-existing drugs, and adverse effect profile. With a growing number of effective antihypertensive agents already available to the clinician, it is not yet clear whether moxonidine represents a significant advance in hypertension management.|*Antihypertensive Agents/adverse effects/pharmacokinetics/therapeutic use[MESH]|*Imidazoles/adverse effects/pharmacokinetics/therapeutic use[MESH]|Animals[MESH]|Blood Pressure/drug effects[MESH]|Central Nervous System/drug effects/metabolism[MESH]|Dose-Response Relationship, Drug[MESH]|Drug Administration Routes[MESH]|Humans[MESH]|Hypertension/*drug therapy/metabolism/physiopathology[MESH]|Imidazoline Receptors[MESH]|Receptors, Drug/agonists/metabolism[MESH]|Safety[MESH]|Treatment Outcome[MESH] |
