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Charged with meaning: the structure and mechanism of phosphoprotein phosphatases Taylor WP; Widlanski TSChem Biol 1995[Nov]; 2 (11): 713-8Many phosphatases require two metal ions for catalysis. New structural information on two serine/threonine phosphatases offers insight into how the metals contribute to catalysis. A comparison with the structures of protein tyrosine phosphatases, which do not use metal ions, shows that the only similarity at the active site is that of charge.|Binding Sites[MESH]|Catalysis[MESH]|Metals/*chemistry/*metabolism[MESH]|Phosphoprotein Phosphatases/*chemistry/*metabolism[MESH]|Protein Conformation[MESH] |
