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lüll General mechanisms of metastasis Woodhouse EC; Chuaqui RF; Liotta LACancer 1997[Oct]; 80 (8 Suppl): 1529-37In the present article, the steps involved in the process of tumor metastasis are discussed. Several events are required for malignant cells to leave the primary tumor and proliferate at a distant site: vessel formation (angiogenesis), cell attachment, invasion (matrix degradation, cell motility), and cell proliferation. Molecular mechanisms underlying each of these steps are described. Based on blocking these processes, new anti-metastasis therapies are being developed.|*Neoplasm Invasiveness[MESH]|*Neoplasm Metastasis/pathology[MESH]|*Neovascularization, Pathologic/metabolism/pathology[MESH]|Bone Neoplasms/secondary[MESH]|Cell Adhesion[MESH]|Cell Adhesion Molecules/physiology[MESH]|Growth Substances/metabolism[MESH]|Humans[MESH]|Tissue Inhibitor of Metalloproteinases/physiology[MESH] |