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lüll Primary anaplastic large-cell lymphoma in adults: clinical presentation, immunophenotype, and outcome Tilly H; Gaulard P; Lepage E; Dumontet C; Diebold J; Plantier I; Berger F; Symann M; Petrella T; Lederlin P; Briere JBlood 1997[Nov]; 90 (9): 3727-34Anaplastic, CD30+, large-cell lymphoma is now a well-recognized pathologic entity that accounts for 2% to 8% of all lymphomas. Recent progress has been made in the understanding of certain biologic features found in anaplastic large-cell lymphoma, but information about its clinical behavior, in comparison to other large-cell lymphomas, is limited. The pathologic review of a large multicenter study of the treatment of aggressive lymphoma identified 146 cases of anaplastic large-cell lymphoma (ALCL) on the basis of morphology and CD30 expression. We compared initial presentation, immunophenotype, and clinical outcome of these cases with those of the 1,695 nonanaplastic diffuse large-cell lymphomas (non-ALCL) included in the same trial. Patients with ALCL were more likely to be male (P = .018) and were younger (P < .0001) than those with non-ALCL. B symptoms were more frequent in ALCL (P = .006). Skin (P < .0001) and lung (P < .05) involvement was also more frequent in ALCL, but frequency of bone marrow involvement was identical (P = . 5). Tumor cell phenotype was B in 56 cases (38%), T in 49 cases (34%), and null in 33 cases (22%). Response to chemotherapy (P = . 001), event-free survival (P = .006), and overall survival (P = . 0004) were better for ALCL than for non-ALCL. Multivariate analyses identified anaplastic character as an independent factor that predicted a longer survival. Tumor cell phenotype did not influence event-free survival (P = .72) or overall survival (P = .83). ALCL in adults is a clinicopathologic entity which, independent of its phenotypic characteristics, has a better outcome than other diffuse large-cell lymphomas.|*Lymphoma, Large-Cell, Anaplastic/immunology/mortality/physiopathology/therapy[MESH]|Adult[MESH]|Aged[MESH]|Combined Modality Therapy[MESH]|Female[MESH]|Humans[MESH]|Immunophenotyping[MESH]|Male[MESH]|Middle Aged[MESH]|Treatment Outcome[MESH] |