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  lüll Rickettsioses as paradigms of new or emerging infectious diseases Raoult D; Roux VClin Microbiol Rev  1997[Oct]; 10 (4): 694-719Rickettsioses are caused by species of Rickettsia, a genus comprising organisms  characterized by their strictly intracellular location and their association with  arthropods. Rickettsia species are difficult to cultivate in vitro and exhibit  strong serological cross-reactions with each other. These technical difficulties  long prohibited a detailed study of the rickettsiae, and it is only following the  recent introduction of novel laboratory methods that progress in this field has  been possible. In this review, we discuss the impact that these practical  innovations have had on the study of rickettsiae. Prior to 1986, only eight  rickettsioses were clinically recognized; however, in the last 10 years, an  additional six have been discovered. We describe the different steps that  resulted in the description of each new rickettsiosis and discuss the influence  of factors as diverse as physicians' curiosity and the adoption of molecular  biology-based identification in helping to recognize these new infections. We  also assess the pathogenic potential of rickettsial strains that to date have  been associated only with arthropods, and we discuss diseases of unknown etiology  that may be rickettsioses.|Africa/epidemiology[MESH]|Animals[MESH]|Arthropods/microbiology/ultrastructure[MESH]|Asia/epidemiology[MESH]|Bacterial Outer Membrane Proteins/genetics[MESH]|Citrate (si)-Synthase/genetics[MESH]|Europe/epidemiology[MESH]|Humans[MESH]|Microscopy, Fluorescence[MESH]|Pacific Islands/epidemiology[MESH]|Phylogeny[MESH]|Rickettsia Infections/classification/*diagnosis/*epidemiology[MESH]|Rickettsia/classification/genetics/*pathogenicity[MESH]|United States/epidemiology[MESH] |