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The role of natural killer cells in viral infections See DM; Khemka P; Sahl L; Bui T; Tilles JGScand J Immunol 1997[Sep]; 46 (3): 217-24Natural killer (NK) cells are important effectors for the lysis of both neoplastic and virus-infected cells. Lectin-like receptors on human NK cells, such as NKR-PIA and CD94, bind to target cell carbohydrate ligands and initiate the lytic process. In addition, P58 and P70 bind to major histocompatibility class I antigens on targets and mediate negative signals. Models using NK cell-deficient mice have proven useful in elaborating the role of NK cells in the immune defence against multiple viral agents. In addition, studies in humans have suggested a vital role of NK cells in the host defence against human immunodeficiency virus, herpesviruses, hepatitis B and C and other viruses. Several genetic disorders, chronic illnesses and infections have been associated with decreased NK function.|*Lectins, C-Type[MESH]|Animals[MESH]|Antigens, CD/metabolism[MESH]|Antigens, Surface/metabolism[MESH]|Cell Death[MESH]|Humans[MESH]|Killer Cells, Natural/*physiology[MESH]|Lectins/metabolism[MESH]|Membrane Glycoproteins/metabolism[MESH]|Mice[MESH]|NK Cell Lectin-Like Receptor Subfamily B[MESH]|NK Cell Lectin-Like Receptor Subfamily D[MESH]|Receptors, Mitogen/metabolism[MESH]|Virus Diseases/*physiopathology[MESH] |
