Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The chemistry and biological profile of trovafloxacin Brighty KE; Gootz TDJ Antimicrob Chemother 1997[Jun]; 39 Suppl B (ä): 1-14The fluoroquinolone antibacterials are noted for their activity after oral administration and potent activity against Gram-negative pathogens. Trovafloxacin (CP-99,219) is a new quinolone antibacterial characterized by a novel 3-azabicyclo[3.1.0]hexyl substituent at the C-7 position, which was discovered in the course of a programme targeting improved activity compared with ciprofloxacin against Gram-positive aerobic organisms and anaerobes, as well as an extended elimination half-life. An overview of the chemical properties of trovafloxacin is given. Trovafloxacin exhibits excellent potency against Gram-positive organisms and anaerobes, while retaining the potent Gram-negative activity of ciprofloxacin. Its pharmacokinetic properties in humans have been shown to be compatible with a once-daily dosing regimen. The combined spectrum and pharmacokinetics of trovafloxacin have been demonstrated to result in excellent efficacy in both animal models of infections and human clinical trials. Phase II and Phase III programmes have been completed.|*Fluoroquinolones[MESH]|Animals[MESH]|Anti-Infective Agents/chemistry/pharmacokinetics/*pharmacology[MESH]|Bacteria, Anaerobic/drug effects[MESH]|Drug Resistance, Microbial[MESH]|Gram-Negative Bacteria/drug effects[MESH]|Gram-Negative Bacterial Infections/drug therapy[MESH]|Gram-Positive Bacteria/drug effects[MESH]|Gram-Positive Bacterial Infections/drug therapy[MESH]|Guinea Pigs[MESH]|Humans[MESH]|Macaca fascicularis[MESH]|Mice[MESH]|Microbial Sensitivity Tests[MESH]|Naphthyridines/chemistry/pharmacokinetics/*pharmacology/therapeutic use[MESH]|Rabbits[MESH]|Structure-Activity Relationship[MESH] |
