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  • The HGF receptor family: unconventional signal transducers for invasive cell growth
  • Comoglio PM; Boccaccio C
  • Genes Cells 1996[Apr]; 1 (4): 347-54
  • The HGF receptor family includes tyrosine kinases encoded by three oncogenes: MET, SEA and RON. The members of this gene family share a unique functional feature: they mediate cell dissociation and motility ('scattering') in physiological conditions, and invasiveness in their activated versions. The Met, Ron and Sea receptors display a distinctive signal transduction behaviour. Unlike conventional growth factor receptors, their cytoplasmic tails contain a multifunctional docking site. Upon autophosphorylation, this sequence simultaneously binds and activates multiple SH2-containing transducers, including Ras and PI 3-kinase. A deregulated activation of this 'supersite' triggers a dramatic pleiotropic signal which is responsible for invasive cell growth.
  • |*Avian Proteins[MESH]
  • |*Cell Transformation, Neoplastic/genetics[MESH]
  • |Animals[MESH]
  • |Cell Division/genetics/*physiology[MESH]
  • |Gene Expression Regulation, Neoplastic[MESH]
  • |Humans[MESH]
  • |Multienzyme Complexes/physiology[MESH]
  • |Phosphorylation[MESH]
  • |Protein-Tyrosine Kinases/physiology[MESH]
  • |Proto-Oncogene Proteins c-met[MESH]
  • |Proto-Oncogene Proteins/genetics/*physiology[MESH]
  • |Receptor Protein-Tyrosine Kinases/genetics/*physiology[MESH]
  • |Receptors, Cell Surface/genetics/*physiology[MESH]
  • |Signal Transduction/*physiology[MESH]

  • *{{pmid9135079}}
    *<b>[ The HGF receptor family: unconventional signal transducers for invasive cell growth ]</b> Genes Cells 1996; 1(4) ; 347-54 Comoglio PM; Boccaccio C


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    Genes Cells

    347 4.1 1996