Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The HGF receptor family: unconventional signal transducers for invasive cell growth Comoglio PM; Boccaccio CGenes Cells 1996[Apr]; 1 (4): 347-54The HGF receptor family includes tyrosine kinases encoded by three oncogenes: MET, SEA and RON. The members of this gene family share a unique functional feature: they mediate cell dissociation and motility ('scattering') in physiological conditions, and invasiveness in their activated versions. The Met, Ron and Sea receptors display a distinctive signal transduction behaviour. Unlike conventional growth factor receptors, their cytoplasmic tails contain a multifunctional docking site. Upon autophosphorylation, this sequence simultaneously binds and activates multiple SH2-containing transducers, including Ras and PI 3-kinase. A deregulated activation of this 'supersite' triggers a dramatic pleiotropic signal which is responsible for invasive cell growth.|*Avian Proteins[MESH]|*Cell Transformation, Neoplastic/genetics[MESH]|Animals[MESH]|Cell Division/genetics/*physiology[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Humans[MESH]|Multienzyme Complexes/physiology[MESH]|Phosphorylation[MESH]|Protein-Tyrosine Kinases/physiology[MESH]|Proto-Oncogene Proteins c-met[MESH]|Proto-Oncogene Proteins/genetics/*physiology[MESH]|Receptor Protein-Tyrosine Kinases/genetics/*physiology[MESH]|Receptors, Cell Surface/genetics/*physiology[MESH]|Signal Transduction/*physiology[MESH] |