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T-call development: is notch a key player in lineage decisions?von Boehmer HCurr Biol 1997[May]; 7 (5): R308-10At two consecutive 'checkpoints' in their development, T cells have to be rescued from programmed cell death and to choose between distinct lineage fates; recent results show that the Notch transmembrane receptor can significantly influence T-cell development at both of these points.|Animals[MESH]|Apoptosis[MESH]|Gene Rearrangement, delta-Chain T-Cell Antigen Receptor[MESH]|Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor[MESH]|Major Histocompatibility Complex[MESH]|Membrane Proteins/*immunology[MESH]|Models, Immunological[MESH]|Receptors, Antigen, T-Cell, alpha-beta/immunology[MESH]|Receptors, Antigen, T-Cell, gamma-delta/immunology[MESH]|Receptors, Cell Surface/immunology[MESH]|Receptors, Notch[MESH]|T-Lymphocyte Subsets/immunology[MESH]|T-Lymphocytes/*immunology/physiology[MESH] |
