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lüll The N-end rule pathway of protein degradation Varshavsky AGenes Cells 1997[Jan]; 2 (1): 13-28The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway.|*Evolution, Molecular[MESH]|*Ligases[MESH]|*Saccharomyces cerevisiae Proteins[MESH]|*Ubiquitin-Protein Ligases[MESH]|Amidohydrolases/*metabolism[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Binding Sites[MESH]|Biological Transport[MESH]|Cytosol/metabolism[MESH]|DNA-Directed RNA Polymerases/metabolism[MESH]|Fungal Proteins/metabolism[MESH]|GTP-Binding Proteins/metabolism[MESH]|Genes, mos[MESH]|Half-Life[MESH]|Molecular Sequence Data[MESH]|Peptide Fragments/chemistry/*metabolism[MESH]|Proteins/chemistry/*metabolism[MESH]|Sindbis Virus/genetics[MESH]|Substrate Specificity[MESH]|Ubiquitins/chemistry/*metabolism[MESH] |