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lüll How did the primordial T cell receptor and MHC molecules function initially?Kurosawa Y; Hashimoto KImmunol Cell Biol 1997[Apr]; 75 (2): 193-6Two genes, designated Trsc-UAA and Trsc-UBA, which encode highly polymorphic major histocompatibility complex (MHC) class I molecules in the shark Triakis scyllia were isolated. The identification of these genes indicates that the classical MHC class I was already established at the level of elasmobranchs during animal evolution. At the emergence of the MHC/T cell receptor recognition system, the number of genes for T cell receptors (TCR) must have been just one. In this brief review, the way in which a small number of TCR could have recognized MHC-oligopeptide complexes initially, based on recent progress in the phylogenetic analysis of the immune systems in primitive vertebrates, is discussed.|Animals[MESH]|Gene Rearrangement, T-Lymphocyte/*immunology[MESH]|Histocompatibility Antigens Class I/*immunology[MESH]|Immunity, Cellular[MESH]|Phylogeny[MESH]|Polymorphism, Genetic[MESH]|Receptors, Antigen, T-Cell/*immunology[MESH]|Sharks/immunology[MESH]|Transplantation, Homologous/immunology[MESH] |