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lüll Epithelial morphogenesis in mouse embryonic submandibular gland: its relationships to the tissue organization of epithelium and mesenchyme Hieda Y; Nakanishi YDev Growth Differ 1997[Feb]; 39 (1): 1-8Epithelial tissues in various organ rudiments undergo extensive shape changes during their development. The processes of epithelial shape change are controlled by tissue interactions with the surrounding mesenchyme which is kept in direct contact with the epithelium. One of the organs which has been extensively studied is the mouse embryonic submandibular gland, whose epithelium shows the characteristic branching morphogenesis beginning with the formation of narrow and deep clefts as well as changes in tissue organization. Various molecules in the mesenchyme, including growth factors and extracellular matrix components, affect changes of epithelial shape and tissue organization. Also, mesenchymal tissue exhibits dynamic properties such as directional movements in groups and rearrangement of collagen fibers coupled with force-generation by mesenchymal cells. The epithelium, during early branching morphogenesis, makes a cell mass where cell-cell adhesion systems are less developed. Such properties of both the mesenchyme and epithelium are significant for considering how clefts, which first appear as unstable tiny indentations on epithelial surfaces, are formed and stabilized.|Animals[MESH]|Basement Membrane/embryology[MESH]|Cell Adhesion[MESH]|Collagen/metabolism[MESH]|Collagenases/pharmacology[MESH]|Epithelium/embryology/metabolism[MESH]|Gestational Age[MESH]|Matrix Metalloproteinase Inhibitors[MESH]|Mesoderm/cytology/metabolism[MESH]|Mice[MESH]|Submandibular Gland/*embryology/metabolism[MESH] |