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lüll Systematic reviews: synthesis of best evidence for clinical decisions Cook DJ; Mulrow CD; Haynes RBAnn Intern Med 1997[Mar]; 126 (5): 376-80Systematic reviews can help practitioners keep abreast of the medical literature by summarizing large bodies of evidence and helping to explain differences among studies on the same question. A systematic review involves the application of scientific strategies, in ways that limit bias, to the assembly, critical appraisal, and synthesis of all relevant studies that address a specific clinical question. A meta-analysis is a type of systematic review that uses statistical methods to combine and summarize the results of several primary studies. Because the review process itself (like any other type of research) is subject to bias, a useful review requires clear reporting of information obtained using rigorous methods. Used increasingly to inform medical decision making, plan future research agendas, and establish clinical policy, systematic reviews may strengthen the link between best research evidence and optimal health care.|*Decision Making[MESH]|*Physicians[MESH]|*Review Literature as Topic[MESH]|Humans[MESH] |