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Wernicke-Korsakoff syndrome Zubaran C; Fernandes JG; Rodnight RPostgrad Med J 1997[Jan]; 73 (855): 27-31Alcohol abuse is one of the most serious problems in public health and the Wernicke-Korsakoff syndrome is one of the gravest consequences of alcoholism. The pathology is often undiagnosed in its less evident presentations, therefore an accurate diagnostic approach is a critical step in treatment planning. Treatment is based on restoration of thiamine, although this is insufficient to prevent the psychological decline of a great number of patients. The cognitive impact of the pathology is derived from the interaction of alcoholic neurotoxicity, thiamine deficiency and personal susceptibility. In this article, the literature concerning Wernicke-Korsakoff syndrome is reviewed.|Alcohol Amnestic Disorder/etiology/history/pathology/*physiopathology/therapy[MESH]|Alcoholism/complications[MESH]|History, 19th Century[MESH]|Humans[MESH]|Metabolic Diseases/etiology/history/pathology/*physiopathology/therapy[MESH]|Prognosis[MESH]|Syndrome[MESH]|Thiamine Deficiency/complications[MESH]|Thiamine/therapeutic use[MESH]|Wernicke Encephalopathy/etiology/history/pathology/*physiopathology/therapy[MESH] |
