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lüll Danazol for paroxysmal nocturnal hemoglobinuria Harrington WJ Sr; Kolodny L; Horstman LL; Jy W; Ahn YSAm J Hematol 1997[Feb]; 54 (2): 149-54Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal stem-cell disorder in which blood cells lack complement inhibiting membrane proteins, and become susceptible to complement-mediated injury, leading to chronic intravascular hemolysis and pancytopenia. Glucocorticoids have been a mainstay of therapy. For patients refractory to glucocorticoids and requiring blood transfusions, an alternative therapy is needed. We studied danazol therapy in 5 patients refractory to other treatments. Four of the 5 benefited, showing rise in hematocrit and eventual cessation of transfusion requirements. Remissions lasted > or =2 years in 3 and 10 years in 1 patient. Danazol was well-tolerated without serious side effects. Danazol appears to be a good alternative treatment in PNH.|*Circadian Rhythm[MESH]|Adolescent[MESH]|Adult[MESH]|Danazol/*therapeutic use[MESH]|Female[MESH]|Hemoglobinuria, Paroxysmal/*drug therapy/*physiopathology[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Remission Induction[MESH] |