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Iron-chelating therapy and the treatment of thalassemia Olivieri NF; Brittenham GMBlood 1997[Feb]; 89 (3): 739-61Iron-chelating therapy with deferoxamine in patients with thalassemia major has dramatically altered the prognosis of this previously fatal disease. The successes achieved with deferoxamine, as well as the limitations of this treatment, have stimulated the design of alternative strategies of iron-chelating therapy, including orally active iron chelators. The development of the most promising of these, deferiprone, has progressed rapidly over the last 5 years; data from several trials have provided direct and supportive evidence for its short-term efficacy. At the same time, the toxicity of this agent mandates a careful evaluation of the balance between risk and benefit of deferiprone in patients with thalassemia, in most of whom long-term deferoxamine is safe and efficacious therapy.|*Chelation Therapy[MESH]|Animals[MESH]|Humans[MESH]|beta-Thalassemia/*drug therapy[MESH] |
