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lüll Mechanisms of interference with the MHC class I-restricted pathway of antigen presentation by herpesviruses Hill ABImmunol Cell Biol 1996[Dec]; 74 (6): 523-6Herpesviruses are an ancient, ubiquitous family of DNA viruses, most of which share a lifestyle of latently or persistently infecting a young host, and spreading to infect a new host a generation later. Most herpesviruses interfere with antigen presentation via the MHC class I-restricted pathway of antigen presentation, suggesting that impairment of the cytotoxic T lymphocyte response is necessary for the maintenance of this lifestyle. The diverse molecular mechanisms that have so far been discovered employed by Epstein-Barr virus, herpes simplex viruses, and human and murine cytomegaloviruses are described in this review.|*Antigen Presentation[MESH]|Animals[MESH]|Herpesviridae Infections/*immunology/*virology[MESH]|Herpesviridae/*immunology/*pathogenicity[MESH]|Histocompatibility Antigens Class I/*physiology[MESH]|Humans[MESH] |