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lüll The phenomenon of rapid cycling in bipolar mood disorders: a review Persad E; Oluboka OJ; Sharma V; Mazmanian D; Kueneman KCan J Psychiatry 1996[Feb]; 41 (1): 23-7OBJECTIVE: To review the various pharmacological and nonpharmacological factors associated with the induction of rapid cycling in bipolar mood disorder, and to introduce the idea that parturition may also have a role. Factors known to contribute to bipolar mood disorder rapid cycling include antidepressant agents, female gender and middle age. Currently, there is evidence that hypothyroidism may also play a role. METHOD: A critical review of the literature was undertaken. CONCLUSION: Caution should be exercised in the use of antidepressants in patients with bipolar mood disorders.|*Periodicity[MESH]|Adult[MESH]|Age Factors[MESH]|Antidepressive Agents/adverse effects/therapeutic use[MESH]|Bipolar Disorder/diagnosis/drug therapy/*etiology[MESH]|Female[MESH]|Humans[MESH]|Hypothyroidism/complications/diagnosis/drug therapy[MESH]|Male[MESH]|Middle Aged[MESH]|Pregnancy[MESH]|Puerperal Disorders/diagnosis/drug therapy/etiology[MESH]|Sex Factors[MESH] |