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Molecular pharmacology of voltage-dependent calcium channels Mori Y; Mikala G; Varadi G; Kobayashi T; Koch S; Wakamori M; Schwartz AJpn J Pharmacol 1996[Oct]; 72 (2): 83-109Voltage-dependent Ca2+ channels serve as the only link to transduce membrane depolarization into cellular Ca(2+)-dependent reactions. A wide variety of chemical substances that have the ability to modulate Ca2+ channels have been demonstrated both for their clinic utility and for importance in elucidating the molecular basis of various biological responses. Recently, introduction of molecular biology to pharmacology has brought a great deal of information about the molecular basis of drug action in Ca2+ channels. In this review, we attempt to overview recent progress in understanding the interactions between Ca2+ channels and their blockers, namely Ca2+ antagonists, from a molecular and structural point of view.|Agatoxins[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Binding Sites[MESH]|Calcium Channel Blockers/metabolism/*pharmacology[MESH]|Calcium Channels/chemistry/*drug effects/metabolism[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Mollusk Venoms/pharmacology[MESH]|Spider Venoms/pharmacology[MESH] |
