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lüll IQI/Jic mice have thymic B cells Saegusa J; Yasuda A; Kubota HExp Anim 1996[Oct]; 45 (4): 353-60The thymus of IQI/Jic mice aged 3 to 15 months was studied chronologically by flow cytometry and immunohistochemistry. Thymic B cells (Thy B) expressing the surface marker B220+IgM+ were detected in both sexes, but were more prominent in females. Thy B appeared as early as 4 months of age in female mice, and the incidence of Thy B-positive mice and average Thy B ratio in thymocytes increased with age, reaching over 90% and 15%, respectively, after 9 months of age. In males, Thy B-positive animals appeared around 9 months of age and its incidence and average ratio increased gradually to 53% and 5%, respectively, at 15 months. The Thy B-rich thymus was thickened with cortical atrophy and medullary hyperplasia. Small- to medium-sized Thy B crowded and often formed follicle-like structures in the medulla. When mice of various ages were injected with mercuric chloride to induce antinucleolar antibody, many Thy B-rich animals could not develop the antibody, implying that these animals are immunologically impaired. IQI/Jic can be a novel strain to elucidate the relationship between the presence of Thy B and disorders of the immune system.|*Aging[MESH]|*Sex Characteristics[MESH]|Animals[MESH]|Antibodies, Antinuclear[MESH]|B-Lymphocytes/chemistry/*cytology[MESH]|Female[MESH]|Flow Cytometry/methods[MESH]|Immunohistochemistry/methods[MESH]|Lymphocyte Count[MESH]|Male[MESH]|Mercuric Chloride[MESH]|Mice[MESH]|Thymus Gland/chemistry/*cytology/growth & development[MESH] |