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Disease mechanism: unravelling Wiskott-Aldrich syndrome Kirchhausen T; Rosen FSCurr Biol 1996[Jun]; 6 (6): 676-8The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.|Cell Cycle Proteins/*metabolism[MESH]|GTP-Binding Proteins/*metabolism[MESH]|Humans[MESH]|Proteins/genetics/*metabolism[MESH]|Wiskott-Aldrich Syndrome Protein[MESH]|Wiskott-Aldrich Syndrome/*metabolism[MESH]|cdc42 GTP-Binding Protein[MESH] |