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English Wikipedia
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Recent progress in oligonucleotide synthesis Pfleiderer W; Matysiak S; Bergmann F; Schnell RActa Biochim Pol 1996[]; 43 (1): 37-44New blocking group combinations for the machine-aided oligoribonucleotide synthesis on solid phase material have been developed and tested regarding their general application. An acetal function for 2'-OH protection offers a series of advantages in the synthetic approach but special conditions have to be fulfilled in order to guarantee a selective cleavage of the temporary 5'-OH blocking group such as the dansylethoxycarbonyl or even the acid-labile dimethoxytrityl group in the chain elongation process. The final removal of the 2'-O-acetal function in the partially deblocked oligomer proceeds unexpectedly well under weak acidic conditions due to a supposed intramolecular acid catalysis.|Acetals[MESH]|Dansyl Compounds[MESH]|Indicators and Reagents[MESH]|Molecular Structure[MESH]|Oligodeoxyribonucleotides/chemical synthesis[MESH]|Oligonucleotides/*chemical synthesis[MESH]|Oligoribonucleotides/chemical synthesis[MESH] |
