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lüll Initial manifestation of primary hyperoxaluria type I in adults-- recognition, diagnosis, and management Kuiper JJWest J Med 1996[Jan]; 164 (1): 42-53Primary hyperoxaluria type I may initially manifest as urolithiasis, renal insufficiency, or symptoms of systemic oxalosis. This hereditary disorder was fatal until effective therapies evolved during the past two decades. Difficulty in recognizing and diagnosing this disorder in adults is illustrated in a report of a patient eventually restored to good health by high-flux dialysis and combined renal and hepatic transplantation. I explore the molecular processes of the genetic defect and discuss clinical indicators of primary hyperoxaluria type I, manifestations of oxalosis, the pathogenesis of chronic oxalate nephropathy, and the diagnosis and management of this disease.|Humans[MESH]|Hyperoxaluria, Primary/*complications/diagnosis/therapy[MESH]|Male[MESH]|Middle Aged[MESH]|Oxalates/metabolism[MESH]|Renal Insufficiency/etiology[MESH]|Urinary Calculi/prevention & control[MESH] |