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The type-1 repeats of thyroglobulin regulate thyroglobulin degradation and T3, T4 release in thyrocytes Molina F; Pau B; Granier CFEBS Lett 1996[Aug]; 391 (3): 229-31Thyroglobulin (Tg) proteolytic steps are central phenomena in Tg processing and thyroid hormone release in thyrocytes. Based on recent literature data, we propose that the type-1 repetitive units present in the Tg sequence could act as binders and reversible inhibitors of the proteases implicated in Tg processing. The pH-dependent interactions of proteases with the repeats could permit (i) protection from degradation of low iodinated Tg to be recycled; (ii) restriction of early proteolytic attacks to N- and C-terminal hormone formation sites; (iii) increase of the half-time of acidic proteases necessary for the final, extensive degradation steps of Tg.|Animals[MESH]|Humans[MESH]|Models, Biological[MESH]|Thyroglobulin/*metabolism[MESH]|Thyroid Gland/cytology/*metabolism[MESH]|Thyronines/*metabolism[MESH]|Thyroxine/*metabolism[MESH] |
