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lüll Neurobehavioral study of borderline personality disorder van Reekum R; Conway CA; Gansler D; White R; Bachman DLJ Psychiatry Neurosci 1993[May]; 18 (3): 121-9The existence of an "organic" subgroup of borderline personality disorder (BPD) has been postulated. This report is of a case-controlled, chart-review study of BPD. The control sample consisted of patients with a variety of psychiatric diagnoses. The study found that 81% of the patients with BPD and 22% of the control patients had a history of brain injury, either developmental (44%), acquired (58%) or both. Furthermore, there was a positive correlation between the summed number of developmental and acquired brain injuries and the score on the retro-Diagnostic Interview for Borderline. A pilot neuropsychological study showed that seven of nine subjects with BPD had evidence of frontal system dysfunction. These results help to support the hypothesized existence of an organic BPD subgroup.|Adult[MESH]|Borderline Personality Disorder/*psychology[MESH]|Brain Diseases/epidemiology/*psychology[MESH]|Brain Injuries/epidemiology/*psychology[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Prevalence[MESH]|Psychiatric Status Rating Scales[MESH]|Retrospective Studies[MESH] |