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lüll McCune-Albright syndrome: how many endocrinopathies can one patient have?Cavanah SF; Dons RFSouth Med J 1993[Mar]; 86 (3): 364-7In this one patient with McCune-Albright syndrome are seen a multitude of endocrinopathies--more than in any case previously described. Only fibrous dysplasia with cafe-au-lait spots and/or endocrine hyperfunction are required for the diagnosis of the syndrome. Our patient has polyostotic fibrous dysplasia, cafe-au-lait spots, and at least four primary endocrinopathies. She had shown precocious puberty (with an ovarian follicular cyst later requiring resection), hyperthyroidism due to toxic nodular thyroid disease, primary hyperparathyroidism, and hyperprolactinemia (with associated hypogonadotropic hypogonadism and premature menopause). With this many organs involved in the same patient, it is hard to imagine that a genetic defect will not soon be identified as the unifying cause of the entire syndrome.|Bromocriptine/therapeutic use[MESH]|Female[MESH]|Fibrous Dysplasia, Polyostotic/blood/*complications/diagnostic imaging[MESH]|Heart Failure/complications/drug therapy/therapy[MESH]|Humans[MESH]|Hyperparathyroidism/*complications/diagnosis/drug therapy[MESH]|Hyperprolactinemia/*complications/diagnosis/drug therapy[MESH]|Hyperthyroidism/*complications/diagnosis/drug therapy[MESH]|Iodine Radioisotopes/therapeutic use[MESH]|Middle Aged[MESH]|Puberty, Precocious/*complications/diagnosis/physiopathology[MESH]|Radiography[MESH] |