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lüll Dynamics of intermediate filaments Recent progress and unanswered questions Georgatos SDFEBS Lett 1993[Mar]; 318 (2): 101-7Intermediate filaments (IFs) have always been considered as the most static and 'skeletal' cellular elements. This view is now changing: new information reveals that IFs exchange subunits at steady-state, that IF networks can be assembled de novo, and that IF proteins are subject to elaborate chemical modification and de-modification during mitosis. I describe below some of the key observations which have made us realize that IFs are dynamic structures. I also discuss some of the remaining questions pertinent to the pathways of IF assembly under in vivo conditions.|Animals[MESH]|Cell Membrane/metabolism/ultrastructure[MESH]|Intermediate Filament Proteins/*physiology[MESH]|Intermediate Filaments/*physiology/ultrastructure[MESH]|Macromolecular Substances[MESH]|Protein Processing, Post-Translational[MESH] |