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lüll Retroviral interference with neuronotrophic signaling in human motor neuron disease?Westarp ME; Westphal KP; Clausen J; Rasmussen HB; Hoff-Jorgensen R; Fohring B; Kornhuber HHClin Physiol Biochem 1993[]; 10 (1): 1-7We tested 13/32 patients with non-familial amyotrophic lateral sclerosis (ALS) positive (41%) for human spuma retrovirus (HSRV) seroreactivity. Half the non-ALS HSRV-positive neurologic patients (12/25) reported multiple fasciculations within the last two years. Sera from four HSRV-env negative ALS patients measurably competed with visna antibodies on maedi-visna antigen. The serologies for bovine leukemia virus, Borna disease virus and GM1IgM-antibodies remained negative. Both visna and foamy virus sequences share epitopes with motor nervous system signal polypeptides, suggesting a retroviral interference with motor neurono-axonal function and neuronotrophic signals.|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Amino Acid Sequence[MESH]|Amyotrophic Lateral Sclerosis/*etiology/immunology[MESH]|Enzyme-Linked Immunosorbent Assay[MESH]|Female[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Molecular Sequence Data[MESH]|Nerve Growth Factors/*immunology[MESH]|Nerve Tissue Proteins/*immunology[MESH]|Protein Sorting Signals/immunology[MESH]|Retroviridae Infections/*complications/immunology[MESH]|Retroviridae Proteins/immunology[MESH]|Spumavirus/*immunology[MESH] |