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The maintenance of self-tolerance Lafferty KJ; Gill RGImmunol Cell Biol 1993[Jun]; 71 ( Pt 3) (ä): 209-14Two signal models for lymphocyte activation build on the Talmage/Burnet concept that receptor diversity is generated within the immune system by a random process, and that individual lymphocytes carry a single receptor on their surface that determines their specificity. Such models cannot use a concept of signal one anergy (or deletion) to explain the maintenance of self-tolerance in terms of the Bretscher/Cohn theory if they abandon the concept of associative recognition.|*Immune Tolerance[MESH]|*Models, Biological[MESH]|Allergy and Immunology/history[MESH]|Animals[MESH]|Autoimmunity[MESH]|History, 20th Century[MESH]|Humans[MESH]|Isoantigens/immunology[MESH]|Lymphocyte Activation/*physiology[MESH]|Signal Transduction/physiology[MESH]|Transplantation Immunology[MESH] |
