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The mammalian Na+/H+ exchanger gene family--initial structure/function studies Tse M; Levine S; Yun C; Brant S; Pouyssegur J; Donowitz MJ Am Soc Nephrol 1993[Oct]; 4 (4): 969-75A gene family of mammalian Na+/H+ exchangers has been identified. Three isoforms have been cloned, sequenced, and stably expressed, and structure/function studies have been begun. Several of the isoforms are found in the epithelia, and one of them is epithelial specific.|*Multigene Family[MESH]|Amiloride/metabolism[MESH]|Animals[MESH]|Binding Sites[MESH]|Humans[MESH]|Ileum/metabolism[MESH]|Molecular Structure[MESH]|Rabbits[MESH]|Rats[MESH]|Sodium-Hydrogen Exchangers/chemistry/*genetics/metabolism[MESH]|Tissue Distribution[MESH] |
