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  • Control of clonal deletion in the thymus: implications for tolerance induction
  • Hartwig M
  • Immunol Cell Biol 1993[Aug]; 71 ( Pt 4) (): 337-40
  • Tolerance to foreign antigen by means of clonal deletion in the thymus can be achieved during embryonic or neonatal life, but not easily in the adult animal. It is concluded here that an immunological control by mature T cells prevents newly acquired antigen from being permanently deposited in the adult thymus. In this way, the originally established thymic antigen discrimination can be maintained successfully. Breakdown of the control circuit should permit tolerance induction even in the adult thymus.
  • |*Clonal Deletion[MESH]
  • |Animals[MESH]
  • |Autoantigens/immunology[MESH]
  • |T-Lymphocytes/immunology[MESH]
  • |Thymus Gland/*immunology[MESH]





  • *{{pmid8225399}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=8225399 Control of clonal deletion in the thymus: implications for tolerance induction ]</b> Immunol Cell Biol 1993; 71 ( Pt 4)() ; 337-40 Hartwig M

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    Immunol Cell Biol

    337 .71 ( Pt 4) 1993