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Low-dose depot medication in schizophrenia Burnett PL; Galletly CA; Moyle RJ; Clark CRSchizophr Bull 1993[]; 19 (1): 155-64Depot antipsychotic medication is a major component of the maintenance treatment of schizophrenia, but it is still not clear what constitutes an appropriate dose. A number of studies comparing low with standard doses of depot antipsychotic medication on a variety of outcome measures have been published in the last decade. A review of these studies indicates that, compared to standard-dose treatment, low-dose medication tends to improve psychosocial function and reduce the frequency of side effects but may result in an increase in positive symptoms. In such cases, a temporary increase in dose appears to control symptoms and terminate relapse episodes. An explanation of the relative efficacy of low-dose treatment may be derived from recent work in radioreceptor ligand binding.|*Schizophrenic Psychology[MESH]|Antipsychotic Agents/*administration & dosage[MESH]|Delayed-Action Preparations[MESH]|Dose-Response Relationship, Drug[MESH]|Humans[MESH]|Psychiatric Status Rating Scales[MESH]|Schizophrenia/*drug therapy[MESH] |
