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lüll Worsening of vasovagal syncope after beta-blocker therapy Wang CC; Yeh SJ; Wen MS; Lin FC; Wu DChest 1994[Sep]; 106 (3): 963-5Head-up tilt test was done in a 27-year-old man with recurrent syncope of unexplained cause. Severe sinus bradycardia and hypotension accompanied by light-headedness, cold sweating, and nausea occurred at 80 degrees head-up position during 4 micrograms/min isoproterenol infusion. Oral propranolol, 160 mg/d, in four divided doses, effectively prevented the above-mentioned abnormal vasovagal reflexes; diltiazem was only partially effective while disopyramide, aminophylline, or atropine was ineffective in preventing the abnormal vasovagal reflexes induced by head-up tilt with isoproterenol infusion. However, the patient experienced ten episodes of syncope in 2 weeks after he was discharged from the hospital on a regimen of atenolol, 50 mg/d. His symptoms ameliorated immediately after discontinuation of atenolol therapy and he became free of severe symptoms while receiving fludrocortisone. Thus, we have documented a patient with worsening of vasovagal syncope after beta-blocker therapy.|Adrenergic beta-Antagonists/*adverse effects[MESH]|Adult[MESH]|Electrocardiography/drug effects[MESH]|Fludrocortisone/therapeutic use[MESH]|Humans[MESH]|Male[MESH]|Posture[MESH]|Recurrence[MESH]|Syncope/*complications/diagnosis/drug therapy[MESH] |